Routes of administration; mechanisms of drug absorption and biological barriers; pharmacokinetic modeling of drug distribution; drug excretion and biotransformation; design and evaluation of controlled release systems, targeted release systems, and responsive release systems.

Engineering approaches to study and control immune reactions and their applications in therapy and diagnostics for infectious disease, cancer, allergy, autoimmunity, and transplantation.

Survey of cardiovascular development, anatomy, physiology and pathology. Recent advances in our understanding of the basic mechanisms of congenital cardiovascular defects and cardiovascular disease. Engineering principles, detection and treatment of cardiovascular defects.

Mathematical and theoretical analysis of the mechanical properties and functions of soft biological tissues to include arterial vessels.

Molecular basis of bioregenerative engineering; biomaterial design; biocompatibility assessment; cell isolation and characterization; rapid prototyping, scaffold fabrication, and biofabrication; protein and gene delivery; bioreactor design; transport in biological tissues; applications of tissue engineering in regenerative medicine.

Course content varies and will be announced in the schedule of classes by title. May be repeated as topic varies.

Analytical and quantitative techniques applied to engineering problems in biomedical transport, tissue mechanics, celluar and organ physiology, and control of medical devices.

Advanced examination of the organization and function of the cell with emphasis on the biophysical and quantitative aspects of cellular function. Emphasis will be on the biomedical engineering applications of regulation of cell division, protein transcription and translation within the cell, cellular energetics, and intracellular networks for cell signaling and cell function.

Conservation of momentum, energy, mass, physico-chemical properties of biofluids, blood rheology, circulation models and cardiovascular regulation, solute and oxygen transport in tissues, gas transport in lungs and respiratory gas exchange models, kinetics and compartmental modeling, modeling of artificial organs.

An examination of human biological structure and function from an engineering perspective. Engineering principles will be used to analyze anatomical structures and physiological functions at the tissue, organ, and systems levels.

Critical reading and literacy in the biomedical engineering discipline as it relates to students’ research. Graduate Standing in the Biomedical Engineering Program.

Individual research to be arranged with the instructor. Graduate Standing in the Biomedical Engineering Program.

Graduate seminar on current topics in biomedical engineering. Instruction on critical analysis and communication in the discipline.

Thesis preparation for Masters Program. Graduate Standing in the Biomedical Engineering Program. Grading: Pass/Fail.

Seminar for doctoral students on current biomedical engineering topics and instruction in professional preparation in the discipline. Graduate Standing in the Biomedical Engineering Program.

Dissertation preparation for the Ph.D. Program. Graduate standing in the Biomedical Engineering program.